INE-1001 is a first-in-class topical ophthalmic formulation containing a PIEZO2 antagonist with a differentiated, non-narcotic, mechanism of action
INE-1001 is being developed for post-surgical ocular pain and is currently under preclinical development progressing towards a first-in-human Phase 1 study to be initiated by 2025 in SpainĀ
Preclinical evidence
In animal models, INE-1001 was well tolerated upon repeated instillation and produced a rapid-onset, dose-dependent selective effect reducing corneal mechanical sensitivity
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